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        公司產品
        Express Technology
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        Rho/Rac/Cdc42 Activator I Rho/Rac/Cdc42活化劑Ⅰ


         Rho/Rac/Cdc42 Activator I Rho/Rac/Cdc42活化劑Ⅰ 零售價:¥0元 品牌:Cytoskeleton 產品編號:CN04-B 等級:活化劑 規格:9 x 20 μg CAS No:

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        詳細信息

        Product Uses Include

        • Activator for Rho pathway

        • Study the effects of Rho activation on cell motility

        • Study the effects of Rho activation on the rearrangement of the actin cytoskeleton

        • Investigate the effects of Rho activation with respect to cross talk with other signal transduction pathways


          The G-switch? Direct Modulators have been developed with an emphasis on creating highly potent cell permeable reagents that directly target the Rho family of small G-proteins.  Our Direct Activator reagents are based on the catalytic domain of the bacterial CNF toxins, which are covalently attached to a proprietary cell penetrating moiety.  Rho Activator II (Cat# CN03) enters the cell and activates Rho GTPase isoforms by deamidating glutamine-63, which is located in the Switch II region of these GTPases (1).  This modification converts glutamine-63 to glutamate, which blocks intrinsic and GAP stimulated GTPase activity resulting in constitutively active Rho (2).  Rho Activator II robustly increases the level of GTP bound RhoA within 2-4 h after addition to the culture medium, providing a more rapid alternative to transfection based methods for introducing activators like GEFs into cells.  Moreover, the targeted action of Rho Activator II makes it far more attractive tool for the study of Rho GTPase signaling than classic indirect activators (e.g. LPA) that concomitantly activate other signaling pathways (e.g. Ras, PI3K and PLC).

           


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          禁断の肉体乱爱中文字幕,忍不住的亲子中文字幕,丰满岳乱妇在线观看中字